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KMID : 0923620180180010008
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Immune Network
2018 Volume.18 No. 1 p.8 ~ p.8
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Regulation of Osteoclast Differentiation by Cytokine Networks
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Amarasekara Dulshara Sachini
Yun Hyeong-Seok
Kim Su-Mi
Lee Na-Ri
Kim Hyun-Jong
Rho Jae-Rang
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Abstract
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Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand play a central role in OC differentiation, which is also termed osteoclastogenesis. Osteoclastogenic cytokines, including tumor necrosis factor-α, IL-1, IL-6, IL-7, IL-8, IL-11, IL-15, IL-17, IL-23, and IL-34, promote OC differentiation, whereas anti-osteoclastogenic cytokines, including interferon (IFN)-α, IFN-β, IFN-γ, IL-3, IL-4, IL-10, IL-12, IL-27, and IL-33, downregulate OC differentiation. Therefore, dynamic regulation of osteoclastogenic and anti-osteoclastogenic cytokines is important in maintaining the balance between bone-resorbing OCs and bone-forming osteoblasts (OBs), which eventually affects bone integrity. This review outlines the osteoclastogenic and anti-osteoclastogenic properties of cytokines with regard to osteoimmunology, and summarizes our current understanding of the roles these cytokines play in osteoclastogenesis.
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KEYWORD
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Cytokines, Osteoclast differentiation factor, Osteoclastogenesis, Osteoimmunology
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